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Technologies Available for Licensing from NIH/FDA
Acute myelogenous leukemia
| eps15, Substrate For The Epidermal Growth Factor Receptor Kinase |
These applications describe eps15, a substrate for the Epidermal Growth Factor Receptor (EGFR). This substrate is distinct from a previously identified substrate for the EGFR known as eps8 (U.S. Patent 5,378,809). EGFR is a cell surface receptor, with tyrosine kinase activity, which has been implicated in mitogenesis via a process known as mitogenic signal transduction. Substrates for the EGFR, such as eps15, may be useful in research on signal t... More ...
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| Adoptive Immunotherapy with Autologous Natural Killer Cells |
Dr. Rosenberg and colleagues have clearly demonstrated that T-lymphocytes can mediate the regression of metastatic melanoma. However, not all patients with cancer are eligible for or respond to this type of immunotherapy. In some patients, the tumor infiltrating lymphocytes (TIL) do not expand sufficiently, or do not exhibit sufficient tumor specific reactivity.
Studies in mice have shown that adoptive transfer of NK cells activated... More ...
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Technologies Available for Licensing from Non-Profit Institutions
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